Vol. 7, Issue 2, Part A (2025)

This study explores the correlation between inherited genetic disorders and environmental factors influencing psychiatric disorders among offspring. Drawing on a sample of families with diagnosed psychiatric conditions, the research investigates how genetic predisposition and environmental stressors jointly contribute to the onset and severity of psychiatric symptoms. Using validated clinical assessments and environmental questionnaires, correlation and regression analyses reveal a significant association between genetic inheritance and psychiatric outcomes, moderated by environmental variables such as socioeconomic status and parental mental health. Findings highlight the complex interplay of genetic and environmental influences in psychiatric morbidity, underscoring the need for integrated preventive strategies. Psychiatric disorders emerge through a complex interplay of genetic predisposition and environmental stressors. This study aimed to investigate the correlation between genetic vulnerability and environmental concerns with psychiatric disorders in an Indian cohort, with a sub-analysis in Jammu & Kashmir (J&K). A cross-sectional design was employed with 400 participants (200 patients with diagnosed psychiatric disorders and 200 matched controls). Genetic vulnerability was assessed through family psychiatric history, while environmental risk factors included childhood trauma, socioeconomic deprivation, and urbanicity. Statistical analysis using Pearson correlation and multivariate regression revealed a significant positive correlation between genetic vulnerability and psychiatric disorders (r = 0.63, p<0.001) and between environmental risk and psychiatric disorders (r = 0.57, p<0.001). Interaction models demonstrated a synergistic gene-environment effect, with individuals at high genetic risk and high environmental stress showing a 4.3-fold increased odds of psychiatric illness (OR = 4.3, 95% CI = 3.1-5.7). The findings underscore the need for integrated screening strategies, especially in high-risk populations such as J&K. Early interventions targeting modifiable environmental risks in genetically vulnerable individuals may reduce disease burden.